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KMID : 0613820070170071023
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Journal of Life Science
2007 Volume.17 No. 7 p.1023 ~ p.1025
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Expression of Ajuba, a Novel LIM Protein, is Regulated by Endoplasmic Reticulum Stress
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Park Sang-Mi
Kwon O-Yu
Goo Tae-Won
Kwon Ki-Sang
Yun Eun-Young
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Abstract
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Ajuba is a number of proteins containing cytosolic LIM domain. Its function may provide a new pathway whereby cell-cell adhesive events are transmitted to the nucleus to regulate cell proliferation and differentiation decisions. Here, Ajuba gene expression was investigated its molecular properties associated with endoplasmic reticulum (ER) stresses (tunicamycin, DTT, A23187 and BFA) which induced remarkable expression of Ajuba mRNA. The mRNA half life of Ajuba was also determined, its half life of Ajuba mRNA in FRTL-5 cells was approximately 2 hr after the initial translation. Although the obvious bioligical function of Ajuba is not clear, on the base of the results, Ajuba gene expression is deeply associated with ER stresses.
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KEYWORD
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Endoplasmic reticulum(ER) stress, Ajuba, mRNA half life
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